Intravenous premedication regimen |
Premedications (last dose immediately prior to infusion of chemotherapy) |
Dexamethasone, 10-20 mg iv every 6 hours for 4 doses |
Cimetidine, 300 mg iv every 8 hours for 3 doses |
Diphenhydramine hydrochloride, 25-50 mg iv every 6 hours for 4 doses |
Optional |
Ondansetron hydrochloride (Zofran), 8 mg iv every 6 hours for 4 doses |
Albuterol nebulizer, 2.5 mg every 6 hours for 4 doses |
Oral premedication regimen |
Premedications |
Dexamethasone, 20 mg po every 6 hours for 4 to 8 doses |
Cimetidine, 300-600 mg po every 8 hours for 3 to 6 doses |
Diphenhydramine hydrochloride, 25-50 mg every 6 hours for 4 to 8 doses |
Optional |
Albuterol multidose inhaler, two puffs administered every 6 hours for 8 doses |
Immediately prior to infusion of chemotherapy |
Dexamethasone, 20 mg iv |
Cimetidine, 300-600 mg iv |
Diphenhydramine hydrochloride, 25-50 mg iv |
Optional |
Lorazepam, 0.5 mg iv |
Ondansetron hydrochloride, 8 mg iv |
May continue dexamethasone, cimetidine, diphenhydramine during infusion |
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