Thrombophilic disorder | Clinical settings and anticoagulants | |||
Acute thrombosis | Heparin therapy | Warfarin | Direct oral anticoagulants* | |
Factor V Leiden | NC | NC | NC | NC |
Prothrombin G20210A | NC | NC | NC | NC |
Protein C (PC) deficiency | NC | NC | Cannot measure¶ | Cannot measure using functional assaysΔ |
Protein S (PS) deficiency | Can be lowered◊ | NC | Cannot measure¶ | Cannot measure using functional assaysΔ |
Antithrombin (AT) deficiency | Can be lowered◊ | Lowered | NC | Cannot measure using functional assyasΔ |
Antiphospholipid antibodies | NC | NC | NC | NC |
Lupus anticoagulant§ | NC | Cannot measureΔ | False positives possible | Cannot measureΔ |
Increased factor VIII activity | Acute phase reactant. Do not test while inflammation is still present. | |||
Acquired AT deficiency: | ||||
Neonatal period; pregnancy; liver disease; DIC; nephrotic syndrome; major surgery; acute thrombosis; treatment with L-asparaginase, heparin, or estrogens | ||||
Acquired protein C deficiency: | ||||
Neonatal period; liver disease; vitamin K deficiency; DIC, chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil; inflammation; treatment with warfarin or L-asparaginase | ||||
Acquired protein S deficiency: | ||||
Neonatal period; pregnancy; liver disease; vitamin K deficiency; DIC; treatment with warfarin, L-asparaginase, or estrogens |
Do you want to add Medilib to your home screen?