Author; year | n | Treatment | Response rate, percent | Limb salvage, percent | Overall survival, percent | Local recurrence, percent | |
Complete | Partial | ||||||
Multicenter studies | |||||||
Eggermont A; 1996 | 55 | TNF+IFN+M | 18 | 64 | 84 | 64 (two-year) | NR |
Eggermont A; 1996 | 186 | TNF±IFN+M | 18 | 57 | 82 | NR | 22 |
Eggermont A; 1999 | 246 | TNF±IFN+M | 28* | 47 | 71 | NR | NR |
Single center studies | |||||||
Gutman M; 1997 | 35 | TNF±IFN+M | 37 | 54 | 85 | NR | 18 |
Olieman A; 1998 | 34 | TNF±IFN+M | 35 | 59 | 85 | NR | 26 |
LeJeune F; 2000 | 22 | TNF±IFN+M | 18 | 64 | 77 | NR | 45 |
Noorda E; 2003 | 49 | TNF±IFN+M | 8 | 55 | 58 | 48¶ (five-year) | 13 |
Grunhagen D; 2005 | 64Δ | TNF±IFN+M | 42 | 45 | 82 | 39 (five-year) | 45 (two-year) |
Lans T; 2005 | 29◊ | TNF±IFN+M | 20 | 50 | 65 | 50 (five-year) | 31 (two-year) |
Bonvalot S; 2005§ | 100 | TNF+M | 49¥ | 17 | 87 | 82 (two-year) | 24 (two-year) |
Grunhagen D; 2006 | 217 | TNF±IFN+M | 18 | 51 | 87 | 49 (five-year) | 26 |
Hayes A; 2007 | 16 | TNF+M | 20 | 33 | 75 | NR | 71 |
Pennacchioli E; 2007 | 88 | Dox+M±TNF‡ | 28 | 52 | 83 | 47 (five-year) | 27 (five-year) |
Van Ginkel R; 2007 | 73 | TNF±IFN+M | 25 | 69 | 61 | 59 (five-year) | 10 (five-year) |
Bonvalot S; 2009§ | 100 | TNF+M | 30¥ | 49 | 87 | 89 (three-year) | 18 (three-year) |
DiFilippo F; 2009 | 75 | TNF+Dox | 34 | 48 | 84 | 62 (five-year) | 21 |
Deroose J; 2011 | 208 | TNF+M | 18 | 53 | 81 | 42 (five-year) 33 (ten-year) | 30 |
Deroose J; 2012 | 29† | TNF+M | 33 | 38 | 87 | 72 (three-year) | 32 |
Olofsson R; 2012 | 54** | TNF+M | 21 | 50 | 76 | 44 (five-year) | 37 |
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