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Scheme of thymic T cell development in alpha-beta T cells

Scheme of thymic T cell development in alpha-beta T cells
Schematic representation of T cell development in the thymus. The various stages of maturation include the DN stages (1, 2, 3, and 4), DP stage, and SP stage. The lower part of the figure indicates TCR2 rearrangements which correspond to each stage. The upper part of the figure demonstrates some of the receptors expressed at each stage of differentiation.
BM: bone marrow; c-kit: a proto-oncogene, also called mast stem cell growth factor receptor; CD: cluster of differentiation; NK: natural killer; TCR: T cell receptor; DN: double negative; IL: interleukin; DP: double positive; SP: single positive; TCR2: T cell receptor type 2 or T cell receptor alpha-beta.
Graphic 76102 Version 10.0

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