Clinical manifestation | Frequency | Typical time of onset | Course |
Manifestations in infancy | |||
Hearing loss | 60% | Early infancy | Permanent |
Heart defect | 45% | ||
Patent ductus arteriosus | 20% | Early infancy | Permanent |
Peripheral pulmonic stenosis* | 12% | Early infancy | Permanent |
Microcephaly | 27% | Neonatal | Permanent |
Cataracts | 25% | Early infancy | Permanent |
Low birth weight (<2500 g) | 23% | Neonatal | Poor weight gain may persist |
Hepatosplenomegaly | 19% | Neonatal | Transient |
Purpura | 17% | Neonatal | Transient |
Developmental delay | 13% | Variable | Permanent |
Meningoencephalitis | 10% | Neonatal | Transient |
Radiolucent bone lesions | 7% | Neonatal | Transient |
Retinopathy | 5% | Early infancy | Permanent |
Late-onset manifestations¶ | |||
Hearing loss | Permanent | ||
Intellectual disability | Permanent | ||
Diabetes mellitus | Permanent | ||
Thyroid dysfunctionΔ | Permanent | ||
Progressive panencephalitis | Permanent |
* Includes pulmonary arterial hypoplasia, supravalvular stenosis, valvular stenosis, and peripheral branch stenosis.
¶ The frequency of these manifestations is not known, given the difficulty of establishing a diagnosis of congenital rubella infection in individuals older than 1 year of age.
Δ Includes hyperthyroidism, hypothyroidism, and thyroiditis.Do you want to add Medilib to your home screen?