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Potential adverse consequences of thrombopoietic growth factor treatment

Potential adverse consequences of thrombopoietic growth factor treatment
Thrombocytosis
Thrombosis
Stimulation of tumor cell growth
Stimulation of leukemia cell growth
Interactions with other cytokines
Autoantibody formation
Reduction in threshold for platelet activation
Increased bone marrow reticulin (positive reticulin stain)
Increased bone marrow collagen (positive trichrome stain)
Rebound worsening of thrombocytopenia upon stopping treatment
Abnormal liver function tests (eltrombopag only)
Iron chelation (eltrombopag only)
Graphic 74625 Version 3.0