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Pathological and virological findings in the arteries of patients who died from VZV vasculopathy

Pathological and virological findings in the arteries of patients who died from VZV vasculopathy
(A) A cerebral artery with multinucleated giant cells (arrow). (B) Multiple herpesvirions within a cerebral artery. (C) VZV DNA in the posterior cerebral artery (lane 3) and basilar artery (lane 5). (D) VZV antigen (red) in the media of a cerebral artery.
Panels A and B courtesy of Don Gilden, MD; Panels C and D reproduced with permission from: Gilden DH, Kleinschmidt-DeMasters BK, Wellish M, et al. Varicella zoster virus, a cause of waxing and waning vasculitis: The New England Journal of Medicine case 5-1995 revisited. Neurology 1996; 47:1441. Copyright © 1996 Lippincott Williams & Wilkins.
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