Ulcerative colitis | Crohn disease | |
Clinical features | ||
Hematochezia | Common | Less common |
Passage of mucus or pus | Common | Rare |
Small bowel disease | No (except backwash ileitis) | Yes |
Can affect upper gastrointestinal tract | No* | Yes |
Abdominal mass | Rare | Sometimes in right lower quadrant |
Extraintestinal manifestations | Common | Common |
Small bowel obstruction | Rarely | Common |
Colonic obstruction | Rarely | Common |
Fistulas and perianal disease | No¶ | Common |
Biochemical features | ||
Antineutrophil cytoplasmic antibodies | Common | Less common |
Anti-Saccharomyces cerevisiae antibodies | Rarely | Common |
Pathologic features | ||
Transmural mucosal inflammation | No | Yes |
Distorted crypt architecture | Yes | Yes |
Cryptitis and crypt abscesses | Yes | Yes |
Granulomas | NoΔ | Yes (seen in 25 to 40% of mucosal biopsies) |
Fissures and skip lesions | Rarely◊ | Common |
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