Melanoma specific structure | Sensitivity (percent) | Specificity (percent) | Positive predictive value (percent) | Negative predictive value (percent) | Odds ratio* | |
Amelanotic melanoma | Pigmented melanoma | |||||
1. Atypical network[1,3,5-14] | 21 | 35-82 | 62-89 | 18-67 | 71-88 | 1.1-9 |
2. Peripheral streaks (pseudopods and radial streaming)[1,3,5-10,13-15] | 5 | 9-32 | 77-99 | 22-77 | 54-86 | 1.6-5.8 |
3. Negative pigment network (asymmetrically located and disordered)[5,16] | 22 | 95 | 1.8 | |||
4. Blotch (off-centered)[13,14] | 4.1-4.9 | |||||
5. Atypical dots and/or globules[3,6,7,13,14] | 24 | 25-40 | 74-92 | 13-79 | 61-86 | 2.9-4.8 |
6. Regression structures | ||||||
Scar-like areas[1,3,5,8] | 23 | 17-36 | 93-99 | 89 | 70 | 4.4-18.3 |
Peppering[3,17] | 22 | 85 | 93-99 | 27 | 99 | 3.5 |
Scar-like areas and peppering[3,5,6,13,14] | 22-42 | 93-99 | 78 | 3.9-7.8 | ||
Blue-white veil overlying macular areas and scar-like areas and peppering[11,12,18] | 44¶ | 91Δ | 3.1-8.7 | |||
7. Blue-white veil overlying raised areas[1,3,5,6,8,9,13,14] | 11 | 17-75 | 86-99 | 52-73 | 55-70 | 2.5-13 |
8. Atypical vascular structures[3,6,10,13,14,19-21] | 63 | 9.4 | 54-96 | 69 | 53 | 1.5-7.4 |
Dotted + serpentine[3] | 30 | 85 | 2.3 | |||
Serpentine vessels[3,22] | 34 | 80 | 68 | 2.1 | ||
Polymorphous vessels[3,22] | 68 | 2.1 | ||||
Milky-red areas[3,22] | 51 | 71 | 77.8 | 2.5 | ||
Red globules[3,22] | 21 | 88 | 2.0 | |||
9. Crystalline structures (also known as Chrysalis and shiny white streaks)[23] | 9.7 | |||||
10. Brown peripheral structureless areas[3,6] | 19 | 63 | 93-96 | 94 | 73 | 2.9-28 |
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