Medicines and other substances likely to be UNSAFE in moderate to severe G6PD deficiency* |
Medications |
Chlorpropamide |
Dabrafenib |
Dapsone (diaminodiphenyl sulfone) |
Fluoroquinolones (ciprofloxacin, moxifloxacin, norfloxacin, ofloxacin)¶ |
Methylene blue (methylthioninium chloride)Δ |
Nalidixic acid◊ |
Nitrofurantoin, nifuratel, and nitrofurazone (nitrofural)◊ |
Phenazopyridine (pyridium) |
Primaquine and tafenoquine |
Rasburicase and pegloticase |
Sulfonylureas (eg, glipizide, glyburide [glibenclamide]) |
Chemical exposures and foods |
Fava beans |
Henna compounds (black and red Egyptian) |
Naphthalene (mothballs, lavatory deodorant) |
Phenylhydrazine |
"RUSH" (isobutyl nitrite, amyl nitrite) |
Medicines that are PROBABLY SAFE given in usual therapeutic doses in G6PD deficiency*; NOTE: some of these were previously considered unsafe; safety in Class I variants is generally not known |
Acetaminophen (Tylenol, Paracetamol) |
Aminophenazone, dipyrone, and metamizole (NSAIDs)◊ |
Antazoline (antihistamine) |
Antipyrine (phenazone) |
Ascorbic acid (vitamin C) |
Aspirin (acetylsalicylic acid) |
Benzhexol (Artane) |
Chloramphenicol |
Chloroquine and hydroxychloroquine |
Colchicine |
Clotrimazole |
Diphenhydramine (Benadryl) |
Isoniazid |
Levodopa (L-Dopa) and levodopa-carbidopa |
Para-aminosalicylic acid |
Para-aminobenzoic acid (PABA) |
Phenylbutazone |
Phenytoin |
Probenecid (Benemid) |
Procainamide (Pronestyl) |
Pyrimethamine (Daraprim) |
Quinine |
Streptomycin |
Sulfa-containing drugs§ (sulfacetamide, sulfadiazine, sulfamethoxazole [Gantanol], trimethoprim-sulfamethoxazole, sulfamethoxypyridazine [Kynex], sulfanilamide, sulfisoxazole [Gantrisin]) |
Tiaprofenic acid |
Trimethoprim |
Tripelennamine (Pyribenzamine) |
Vitamin K |
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