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Classifications of drug-induced liver injury

Classifications of drug-induced liver injury
Type of classification Examples
Clinical laboratory Hepatocellular
Cholestatic
Mixed hepatocellular/cholestatic
Mechanism of hepatotoxicity Direct hepatotoxicity
Idiosyncratic
Immune-mediated
Metabolic
Histologic findings Cellular necrosis or apoptosis
Cholestasis
Steatosis
Fibrosis
Phospholipidosis
Granulomatous
Sinusoidal obstruction syndrome
Graphic 74021 Version 2.0