Abnormality | Causes |
Hypothalamic dysfunction | Isolated GnRH deficiency |
Functional hypothalamic amenorrhea | |
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Inflammatory or infiltrative diseases | |
Brain tumors – eg, craniopharyngioma | |
Cranial irradiation | |
Traumatic brain injury | |
Other syndromes – Prader-Willi, Laurence-Moon-Biedl, leptin mutations | |
Pituitary dysfunction | Hyperprolactinemia, including lactotroph adenomas |
Other pituitary tumors – acromegaly, corticotroph adenomas (Cushing's disease) | |
Other tumors – meningioma, germinoma, glioma | |
Genetic causes of hypopituitarism | |
Empty sella syndrome | |
Pituitary infarct or apoplexy | |
Ovarian dysfunction | Primary ovarian insufficiency (premature ovarian failure) |
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Other | Polycystic ovary syndrome |
Hyperthyroidism | |
Hypothyroidism | |
Uncontrolled diabetes mellitus types 1 and 2 | |
Exogenous androgen use |
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