Method | Problems |
Clinical evaluation | Nonstandardization of physician criteria for diagnosis; bias toward more severe cases; bias by access to physician |
Questionnaire history of diagnosis | Same as above; plus recall bias in subjects |
Questionnaire history of symptoms | Possibly influenced by frequency of other symptoms; less specific than physician's diagnosis |
Response to bronchodilator | May be influenced by level of FEV1*; may lack sensitivity |
Bronchoconstrictor response | Influenced by level of FEV1*; may be nonspecific |
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