Reference | Number of patients | Radiotherapy | Antiemetic | Complete response (percent) | Results |
Tiley1 | 20 | 10.5 Gy (TBI, single fraction) | OND (8 mg IV) | 90* | OND better than placebo |
Placebo | 50* | ||||
Spitzer2 | 20 | TBI: 13.2 Gy in 11 fractions over 4 days | OND (8 mg x 3/day PO) | 50 | OND better than placebo |
Placebo | 0 | ||||
Prentice3 | 30 | 7.5 Gy (TBI, single fraction) | GRAN (3 mg IV) | 53 | GRAN better than MTC + DEX + LOR |
MCP (20 mg IV) + DEX (6 mg/m2 IV) + LOR (2 mg IV) | 13 | ||||
Huang4 | 116 | 7 to 7.7 Gy (TBI, single fraction) | OND (8 mg) + DEX (10 mg) | 84 | OND + DEX better than MCP + DEX |
MCP (10 mg) + DEX (10 mg) | 20 | ||||
Sykes5 | 66 | 8 to 12.5 Gy (HBI, single fraction) | OND (8 mg x 2 PO) | 94 | OND better than CLP + DEX |
CLP (25 mg x 3 PO) + DEX (6 mg x 3 PO) | 34 | ||||
Spitzer6 | 34 | TBI: 13.2 Gy in 11 fractions over 4 days | OND (8 mg x 3/day PO) | 47 | No difference |
GRAN (2 mg x 1/day PO) | 61 |
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