Study | n | Median follow-up | Melanoma thickness | Margins | Local recurrence (%) | Overall survival (%) |
World Health Organization[1] | 612 | 12 years | 0 to 1 mm | 1 cm | 3/186 (1.6) | 87 |
1.1 to 2 mm | 1 cm | 5/119 (4.2) | ||||
0 to 1 mm | 3 cm | 1/173 (0.6) | 85 | |||
1.1 to 2 mm | 3 cm | 2/134 (1.5) | ||||
Swedish[2] | 989 | 11 years | 0.8 to 2 mm | 2 cm | 3/476 (0.6) | 79 |
5 cm | 5/513 (1) | 76 | ||||
French Cooperative Group[3] | 326 | 16 years | <2.1 mm | 2 cm | 1/181 (0.05) | 87 |
5 cm | 4/185 (0.2) | 86 | ||||
Melanoma Intergroup Trial[4] | 468 | 8 years | 1 to 4 mm | 2 cm | (2.1) | 80 |
4 cm | (2.6) | 84 | ||||
British Trial[5] | 900 | 60 months | ≥2 mm | 1 cm | 15/453 (3.3) | No significant difference |
3 cm | 13/457 (2.8) | |||||
Europe[6,7]* | 936 | 6.7 years | >2 mm | 2 cm | 20/465 (4.3) | 65 |
4 cm | 9/471 (1.9) | |||||
19.6 years | >2 mm | 2 cm | Not reported | 52¶ | ||
4 cm | 48¶ |
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