Cardinal features | Relative frequency | |
Myxedema coma | Decreased mental status, bradycardia, hypothermia, hypotension, others | Rare |
Cognitive impairment | Slowed mentation, poor concentration and short-term memory | Common in overt hypothyroidism; uncertain in subclinical hypothyroidism |
Cerebellar ataxia | Gait most often affected, limb and speech involvement can occur | Uncertain; early studies suggest 10 to 30 percent |
Carpal tunnel syndrome | Pain, numbness, weakness in median nerve distribution | Common 25 to 33 percent |
Peripheral neuropathy | Predominantly sensory, often painful | Common, but rarely the presenting symptom |
Myopathy | Ranges from asymptomatic serum CK elevation to cramps and myalgias to more disabling proximal muscle weakness | Common in at least one form |
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