Tumors from individuals should be tested for MSI in the following situations: |
1. Colorectal cancer diagnosed in a patient who is less than 50 years of age. |
2. Presence of synchronous, metachronous colorectal, or other HNPCC-associated tumors*, regardless of age. |
3. Colorectal cancer with the MSI-H¶-like histologyΔ diagnosed in a patient who is less than 60 years of age◊. |
4. Colorectal cancer diagnosed in a patient with one or more first-degree relatives with an HNPCC-related tumor, with one of the cancers being diagnosed under age 50 years. |
5. Colorectal cancer diagnosed in a patient with two or more first- or second-degree relatives with HNPCC-related tumors, regardless of age. |
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