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Structure model of the TSH receptor

Structure model of the TSH receptor
Stimulating (in Graves' disease) and blocking (in Hashimoto's thyroiditis) anti-TSH receptor antibodies may bind to different regions of the ECD.
ECD: extracellular domain; TSH: thyroid-stimulating hormone.
Structure model created using VMD: Humphrey W, Dalke A, Schulten K. VMD: visual molecular dynamics. J Mol Graph 1996; 14:33. Reproduced with permission from Mihaly Mezei, PhD.
Graphic 72949 Version 4.0