At least one of the following: |
- One or more typical phenotypic features of CF:
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- Chronic pulmonary disease
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- Characteristic gastrointestinal and nutritional abnormalities
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- History of CF in a sibling
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- Positive newborn screening test
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PLUS at least one of the following: |
- Elevated sweat chloride concentration
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- Two CFTR gene mutations known to cause CF on separate alleles*
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- Abnormalities in NPD testing that are typical for CF¶
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