Heredity | Chromosomal instability pathway | Mismatch repair pathway | Serrated/CIMP pathway | Hybrid pathway | |
Hereditary and sporadic | Hereditary | Hereditary and sporadic | Sporadic | ||
CIMP status | Negative | Negative | High | High | Low |
MSI status | MSS | MSI-H | MSI-H | MSI-L | MSI-L or MSS |
Chromosomal instability | Present | Absent | Absent | Absent | Present |
KRAS mutation | +++ | +/- | --- | --- | +++ |
BRAF mutation | --- | --- | +++ | +++ | --- |
MLH1 status | Normal | Mutation | Methylated | Partial methylation | Normal |
MGMT methylation | --- | --- | +/- | +++ | +++ |
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