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VWF multimer analysis

VWF multimer analysis
Agarose gel electrophoresis (1.0 percent) of plasma followed by fixation and exposure to a monospecific radiolabeled antibody to VWF. The highest molecular weight multimers of VWF are at the top of the gel (arrow). Lane 1 - severe vWD (type 3) plasma, lane 2 - normal pooled plasma, lane 3 - type 2A plasma, lane 4 - type 2B plasma, lane 5 - vWF extracted from platelets.
From Rick, ME, Diagnosis and management of von Willebrand's syndrome, Med Clin North Am 1994; 78:609.
Graphic 71943 Version 2.0