Adhesion molecule | Cellular expression for leukocyte migration |
Integrins | |
LFA-1 (CD11a/CD18b) | Present on lymphocytes |
Mac-1 (CR3, CD11b/CD18b) | Present on neutrophils and monocytes |
gp 150/95 (CD11c/CD18b) | Present on neutrophils and monocytes |
VLA-4 | Present on lymphocytes, monocytes, and eosinophils |
Immunoglobulin superfamily | |
ICAM-1 | Low-level constitutive endothelial cell expression |
Increased endothelial cell expression with stimulation | |
ICAM-2 | High-level constitutive endothelial cell expression |
No increase with stimulation | |
VCAM-1 | No constitutive endothelial cell expression |
Increased endothelial cell expression with stimulation | |
Selectins | |
P-selectin | Platelet and endothelial cell surface expression after stimulation |
E-selectin | Exclusively expressed on stimulated endothelial cells |
L-selectin | Constitutively expressed on neutrophils, monocytes, and a T cell subset |
Shed from neutrophils after stimulation with chemoattractants |
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