Risk | Diagnosis | Marrow reserve | T/B immunity | Relation to ANC |
Low to no risk | Chronic benign | Normal | Normal | No |
Duffy-null associated neutrophil count (DANC) | Normal | Normal | No | |
Post infectious | Normal/mild decrease | Normal | Yes/no | |
Hypersplenism | Normal/increased | Depends on cause of hypersplenism | No | |
Moderate risk | Transient neonatal neutropenia | Variable | Normal | Yes |
Post infectious | Decreased | Normal | Yes/no | |
Drug induced | Decreased/normal | Normal | Yes | |
Cyclic | Variable | Normal | Yes | |
Nutritional | Variable | Normal/variable | Yes | |
Immune (antibody mediated) | Normal | Abnormal | No | |
Immune (SLE, CVID) | Variable | Abnormal T/B | No/yes | |
High risk | LDLGL, PWCA | Very decreased to absent | Abnormal T cells | Yes |
Shwachman | Decreased | Normal/? | Yes | |
Kostmann | Decreased | Normal/? | Yes | |
Drug induced | Very decreased to absent | Abnormal | Yes | |
Antineoplastic chemotherapy | Very decreased to absent | Abnormal T/B | Yes | |
Aplastic anemia | Decreased/absent | Probably abnormal T cells | Yes | |
Marrow infiltration/MDS/leukemia | Decreased/absent | Probably abnormal | Yes |
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