Class | Antibiotic | Adult dose | Pediatric dose* | Comments |
Tetracyclines | Doxycycline | 300 mg (single dose) | 4 to 6 mg/kg (single dose)¶[1] |
|
Tetracycline | 500 mg 4 times per day for 3 days | 12.5 mg/kg per dose, 4 times per day for 3 days | ||
Macrolides | Azithromycin | 1 g (single dose) | 20 mg/kg (single dose) |
|
Erythromycin | 500 mg 4 times per day for 3 days[5] | 12.5 mg/kg per dose, 4 times per day for 3 days | ||
Fluoroquinolones | Ciprofloxacinפ | 500 mg twice daily for 3 days | 15 mg/kg per dose, twice daily for 3 days |
|
* Maximum pediatric dose is not to exceed adult dose listed.
¶ A pediatric dose of 4 mg/kg is roughly equivalent to an adult dose of 200 mg; a pediatric dose of 6 mg/kg is roughly equivalent to an adult dose of 300 mg. In children >6 years of age, the higher dose of 6 mg/kg has been associated with shorter duration of diarrhea compared with lower doses[7].
Δ Single-dose doxycycline is unlikely to cause dental staining or adverse effects in children, and short-term use is permitted by American Academy of Pediatrics in children of all ages[8]; Centers for Disease Control and Prevention (CDC) and Global Task Force on Cholera Control (GTFCC) consider single-dose doxycycline appropriate for use in children and pregnant patients in the absence of resistance[9,10].
◊ Dose reduction may be needed in patients with kidney impairment (CrCl <30 mL/minute).
§ We recommend a 3-day course of ciprofloxacin in the setting of decreasing susceptibility to fluoroquinolones[11]. For isolates with decreased fluoroquinolone susceptibility (identified by resistance to nalidixic acid), fluoroquinolone regimens administered for 3 days have been associated with higher rates of clinical and bacteriologic response than single-dose regimens.
¥ CDC and GTFCC consider ciprofloxacin appropriate for use in children and pregnant patients in the absence of resistance[9,10].Do you want to add Medilib to your home screen?