Prognosis (EFS) | Stage | Clinical group | Site | Size | Age | FOXO1 fusion status* | Mets | Nodes |
Excellent (>85%) Low risk subset A | 1 | I | Favorable | a or b | <21 | Negative | M0 | N0 |
1 | II | Favorable | a or b | <21 | Negative | M0 | N0 | |
1 | III | Orbit only | a or b | <21 | Negative | M0 | N0 | |
2 | I | Unfavorable | a | <21 | Negative | M0 | N0 or NX | |
1 | II | Favorable | a or b | <21 | Negative | M0 | N1 | |
Very good (70 to 85%) Low risk subset B | 1 | III | Orbit only | a or b | <21 | Negative | M0 | N1 |
1 | III | Favorable, excluding orbit | a or b | <21 | Negative | M0 | N0 or N1 or NX | |
2 | II | Unfavorable | a | <21 | Negative | M0 | N0 or NX | |
3 | I or II | Unfavorable | a | <21 | Negative | M0 | N1 | |
3 | I or II | Unfavorable | b | <21 | Negative | M0 | N0 or N1 or NX | |
Good (50 to 70%) Intermediate risk | 2 | III | Unfavorable | a | <21 | Negative | M0 | N0 or NX |
3 | III | Unfavorable | a | <21 | Negative | M0 | N1 | |
3 | III | Unfavorable | b | <21 | Negative | M0 | N0 or N1 or NX | |
1, 2, 3 | I, II, III | Favorable or unfavorable | a or b | <21 | Positive | M0 | N0 or N1 or NX | |
4 | IV | Favorable or unfavorable | a or b | <10 | Negative | M1 | N0 or N1 or NX | |
Poor (<30%) High risk | 4 | IV | Favorable or unfavorable | a or b | ≥10 | Negative | M1 | N0 or N1 or NX |
4 | IV | Favorable or unfavorable | a or b | <21 | Positive | M1 | N0 or N1 or NX |
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