Antimicrobial agent | Daily intraventricular dose |
Amikacin | 5 to 50 mg* |
Colistin | 10 mg colistimethate sodium (CMS), which corresponds to:
|
Daptomycin | 2 to 5 mgΔ |
Gentamicin | 1 to 2 mg◊ in children 4 to 8 mg◊§ in adults |
Polymyxin B | 2 mg in children 5 mg in adults |
Quinupristin/dalfopristin | 2 to 5 mg |
Tobramycin | 5 to 20 mg |
Vancomycin | 5 to 20 mg◊§¥ |
* The usual intraventricular dose is 30 mg daily.
¶ The formulation available in the United States is measured as colistin base activity. The total daily dose can be administered as one daily dose or divided into two doses given every 12 hours.
Δ One study used 10 mg every day for 2 days and then 10 mg every 48 hours. Another study used 5 mg or 10 mg every 72 hours. Data are based on isolated case reports.
◊ Recommendations for frequency of administration based on external ventricular drain output over 24 hours as follows:§ Dosage recommendations in adults based on ventricle size/volume as follows:
¥ Most studies used a 10 mg or 20 mg dose.
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