Risk | RET codon mutation | Recommended age to begin annual screening for MTC* | Recommended timing of prophylactic thyroidectomy¶ |
Highest | 918 | Not applicable | In the first months to year of life |
High | 634, 883 | 3 years | At or before age 5 years |
Moderate | 533, 609, 611, 618, 620, 630, 666, 768, 790, 804, 891, 912 | 5 years | Childhood or young adulthood |
MTC: medullary thyroid cancer; MEN2: multiple endocrine neoplasia type 2.
* Annual physical examination, neck ultrasound, and measurement of serum calcitonin.
¶ Patients with MEN2 and a diagnosis of MTC (regardless of age) must have pheochromocytoma excluded prior to thyroidectomy.Do you want to add Medilib to your home screen?