TIMI (1988) | GUSTO (1997) | ISAR trials* (2000-05) | ACUITY (2006) | REPLACE-2 (2007) | HORIZONS AMI (2009) |
Intracranial bleed | Intracranial bleed | Intracranial bleed | Intracranial or intraocular | Intracranial, intraocular, or retroperitoneal | Intracranial or intraocular |
Hgb ↓ >5 g/dL or Hct ↓ >15 percent | Hgb ↓ >5 g/dL or Hct ↓ >15 percent | Hgb ↓ ≥3 g/dL with overt bleeding Any Hgb ↓ ≥4 g/dL | Hgb ↓ ≥3 g/dL with overt bleeding Any Hgb ↓ ≥4 g/dL | Hgb ↓ ≥3 g/dL with overt bleeding Any Hgb ↓ ≥4 g/dL | |
Any transfusion | Transfusion ≥2 units of PRBCs | Any transfusion | |||
Hemodynamic compromise requiring intervention | Access site bleeding requiring intervention Hematoma ≥5 cm Reoperation for bleeding | Access site bleeding requiring intervention Hematoma ≥5 cm Reoperation for bleeding |
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