Trial | N/n | Follow-up (months) | Treatment | Clinical fracture rate (%) |
AI versus TAM | ||||
ATAC[1] | 6186/577 | 68 | ANA versus TAM | 11.0 versus 7.7 [p<0.0001] |
BIG 1-98[2] | 4895/352 | 51 | LET versus TAM | 8.6 versus 5.8 [p<0.001] |
AI after two to three years of TAM | ||||
IES[3] | 4724/277 | 58 | EXE versus TAM | 7.0 versus 5.0 [p = 0.003] |
TEAM[4] | 9736/415 | 61 | EXE versus TAM | 5 versus 3 [p<0.0001] |
ABCSG8/ARNO[5] | 3224/50 | 28 | ANA versus TAM | 2.0 versus 1.0 [p = 0.015] |
AI after five years of TAM | ||||
MA-17[6] | 5187/256 | 30 | LET versus placebo | 5.3 versus 4.6 [p = 0.25] |
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