Eosinophilic esophagitis

Esophageal biopsies from a patient with eosinophilic esophagitis. There is severe active esophagitis characterized by marked basal zone hyperplasia (top panel) and large numbers of eosinophils (greater than 40 per high power field, bottom panel). Biopsies obtained from the proximal, mid and distal esophagus showed similar findings. The long linear extent of the esophagitis plus the large numbers of eosinophils are characteristic pathologic features of eosinophilic esophagitis.