Schematic representation of the structure of the T3 nuclear receptor
Schematic representation of the structure of the T3 nuclear receptor
The region labeled "DNA binding" is the portion of the receptor that binds to DNA, and the region labeled "ligand binding" is the region that binds T3. NH2 denotes the amino-terminal end of the receptor and COOH the carboxy-terminal end.
Adapted from: Utiger RD. The thyroid: Physiology thyrotoxicosis, hypothyroidism, and the painful thyroid. In: Endocrinology and Metabolism, 3rd ed, Felig R, Baxter JD, Frohman LA (Eds), McGraw-Hill, NY 1995.