Pathways of cytochrome P450-catalyzed cyclophosphamide metabolism

Reproduced with permission from: Takada, K, Arefayene, M, Desta, Z, et al. Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis. Arthritis Rheum 2004; 50:2202. Copyright© 2004 American College of Rheumatology. Permission from John Wiley & Sons.