Metabolic complications induced by bendrofluazide in relation to daily dose (multiply by 10 to get equivalent doses of hydrochlorothiazide). Increasing the dose led to progressive hypokalemia and hyperuricemia and a greater likelihood of a mild elevation in the FBG, all without a further reduction in the systemic blood pressure. Each treatment group contained approximately 52 patients.
FBG: fasting blood glucose.
Data from: Carlsen JE, Kober L, Torp-Pedersen C, Johansen P. Relation between dose of bendrofluazide, antihypertensive effect, and adverse biochemical effects. BMJ 1990; 300:975.