Syndrome | Recommendation |
Acute pulmonary: moderately severe to severe | Liposomal AmB 3 mg/kg/day IV or AmB lipid complex 5 mg/kg/day IV or AmB deoxycholate* 0.7 to 1 mg/kg/day IV for one to two weeks followed by itraconazole load¶ then 200 mg PO twice daily for a total of 12 weeks |
Methylprednisolone, 0.5 to 1 mg/kg/day IV for one to two weeks for respiratory complications (eg, hypoxemia or respiratory distress) | |
Acute pulmonary: mild to moderate | Symptoms <4 weeks: none |
Symptoms >4 weeks: itraconazole load¶ then 200 mg once or twice daily for 6 to 12 weeks | |
Chronic cavitary pulmonary | Itraconazole load¶ then 200 mg once or twice daily for at least 12 monthsΔ◊ |
Mediastinal granuloma | Asymptomatic: none |
Symptomatic: itraconazole load¶ then 200 mg once or twice daily for 6 to 12 weeks | |
Mediastinal fibrosis | Antifungal treatment not recommendedΔ |
Stenting of obstructed vessels can be useful | |
Broncholithiasis | None |
Bronchoscopic or surgical removal of the broncholith is recommended | |
Pulmonary nodule | None |
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