Gene name or product | Gene | Hypothesized function | Notes |
Catechol-O-methyl transferase | COMT | Catecholamine (including dopamine) metabolism | At position 158 in the resulting protein: a VAL/VAL allele is more active than a VAL/MET or MET/MET allele. The VAL/VAL allele is associated with greater risk of psychosis in cannabis users[1]. Position 22q11. |
D-amino acid oxidase activator/D-amino acid oxidase | DAOA/G30 and DAO | DAO breaks down D-serine, which is an NMDA receptor cofactor | DAOA/G30 and DAO are an interacting pair of genes[2]. |
Disrupted in schizophrenia 1 | DISC1 | Wide array of hypothesized functions from cell migration during development to dendritic outgrowths and cell adhesion | Discovered from studying a Scottish family with many members having a severe mental disorder and also a translocation disrupting the expression of the gene. Position 1q42. |
Dystrobrevin binding protein 1 (dysbindin) | DTNBP1 | Axon stability | Also associated with skeletal muscle. Position 6p22. |
Gamma-aminobutyric acid (GABA) A receptor subunit beta 2 | GABRB2 | Inhibitory neurotransmission | There is evidence of GABA signaling system abnormalities in schizophrenia. Position 5q34. |
Neuregulin 1 | NRG1 | Signal transduction related to cell growth and differentiation | NRG1 undergoes alternative splicing into several proteins. Position 8p12-21. |
Zinc finger protein 804A | ZNF804A | Unknown (may be transcription factor) | Identified in GWAS study[3]. Also associated with bipolar disorders. Examination of rare alleles of the gene found no difference in rates in schizophrenia compared to controls[4]. |
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