Diagnosis, [reference] | Age | Procedure and outcome |
Acetaminophen | ||
[1] | 16 years | Intraportal (4×107 cells), NH3 ↓, encephalopathy grade 4 unchanged. Died on day 2. |
[7] | 26 years | Intrasplenic (1.2×109 cells), NH3 ↓ and encephalopathy grade 4 improved, day 2 OLT, full recovery. |
Isoniazid | ||
[1] | 12 years | Intraportal (1×108 cells × 3), NH3 ↓, encephalopathy grade 4 unchanged. Died on day 7. |
Phenytoin | ||
[1] | 10 years | Intraportal (2.8×109 cells × 3), NH3 ↓, encephalopathy grade 4 unchanged. Died of viral meningitis on day 7. |
Dilantin | ||
[2] | 13 years | Intraportal (1×109 cells), encephalopathy grade 4 unchanged. Died on day 4. |
[7] | 27 years | Intrasplenic (2.8×107), NH3 ↓ and encephalopathy grade 4 improved, day 10 OLT, full recovery. |
Tegretol | ||
[3] | 14.8 years | Intraportal (2.5×109 cells), NH3 ↓, encephalopathy grade 4 improved. OLT on day 1. Full recovery, 6 year follow-up. |
Idiopathic | ||
[1] | 3 years | Intraportal (4×109 cells × 9). NH3 ↓ and encephalopathy improved. Full recovery. |
[1] | 5 years | Intraportal (2×109 cells × 7). NH3 ↓ and encephalopathy grade 4 improved. OLT on day 4. Full recovery. |
[4] | 3.5 months | Intraportal (1.8×108 cells). Encephalopathy unchanged. OLT on day 1. Full recovery. |
[5] | 8 years | Intraperitoneal (6×107 fetal liver cells/kg body weight). Encephalopathy grade 3 improved, full recovery. |
Halothane | ||
[2] | 43 years | Encephalopathy grade 4 improved. Died on day 35 from sepsis. |
Polysubstance use disorder | ||
[6] | 32 years | Intrasplenic (1.3×109 cells), NH3 ↓ and encephalopathy grade 4 improved to grade 2. Died on day 14 from sepsis. |
[6] | 35 years | Intrasplenic (1×1010 cells), NH3 ↓ and encephalopathy grade 4 improved. Died on day 20 from sepsis. |
[3] | 21 years | Intrasplenic (9×108 cells × 2 and 2.5×107 × 1), encephalopathy grade 4 unchanged, day 1 brain death. |
[3] | 35 years | After OLT, intraportal (5.4×109 cells), NH3 ↓ and encephalopathy grade 4 improved. Died on day 18 from sepsis. |
[3] | 35 years | Intraportal, (3.7×109 cells), NH3 ↓ and encephalopathy grade 4 improved, full recovery with more than 1 year follow-up. |
[3] | 51 years | Intraportal (3.9×109 cells), NH3 ↓ and encephalopathy grade 4 improved, died of mesenteric thrombosis on day 3. |
[6] | 32 years | Intraperitoneal (6×107 fetal hep/kg), encephalopathy grade 4 unchanged. Died after 30 hours. |
[6] | 29 years | Intraperitoneal (6×107 fetal hep/kg), encephalopathy grade 4 unchanged. Died after 37 hours. |
[6] | 20 years | Intraperitoneal (6×107 fetal hep/kg), encephalopathy grade 4 unchanged, Died after 48 hours. |
[6] | 20 years | Intraperitoneal (6×107 fetal hep/kg), encephalopathy grade 4 improved, full recovery. |
[6] | 24 years | Intraperitoneal (6×107 fetal hep/kg), encephalopathy grade 3 improved, full recovery. |
Chloroform, alcohol | ||
[6] | 55 years | Intrasplenic (3.9×1010 cells), encephalopathy grade 4 unchanged, multisystem organ failure at 6 hours. |
Neonatal hemochromatosis | ||
[10] | 3 days | Intraperitoneal injection of (2.5×107/kg) alginate encapsulated hepatocytes. INR normalized by day 10. Patient survived without liver transplantation. |
[10] | 1 day | Two intraperitoneal injections (2.4×107/kg and 3×107/kg) alginate encapsulated hepatocytes. INR continued to be abnormal. Patient received liver transplantation on day 28. |
[10] | 14 days | Intraperitoneal injection of (2×107/kg) alginate encapsulated hepatocytes. INR normalized by day 35. Patient survived without liver transplantation. |
[10] | 41 days | Two intraperitoneal injections (3×107/kg and 2.3×107/kg) alginate encapsulated hepatocytes. INR continued to be abnormal. Patient received liver transplantation on day 44. |
Etiology unknown | ||
[8] | 23 years | Intrasplenic, (2.86×108 and 1.52×108 cells), NH3 ↓, and encephalopathy grade 3 improved, OLT on day 5, multisystem organ failure on day 13. |
[10] | 6 years | Intraperitoneal injection of (1.5×107/kg) alginate encapsulated hepatocytes. INR remained persistently abnormal until patient received liver transplantation on day 8. |
[10] | 8 days | Intraperitoneal injection of (2.6×107/kg) alginate encapsulated hepatocytes. INR increased on day 1. Patient died on day 1. |
Reyes syndrome | ||
[3] | 48 years | Intraportal, (7.5×108 cells), NH3 ↓, encephalopathy grade 4 unchanged, brain death on day 1. |
Amanita phalloides | ||
[8] | 64 years | Intraportal, (4.9×109 cells), NH3 ↓ and encephalopathy grade 4 improved, full recovery, off immunosuppression 12 weeks. |
Post-surgical trisegmentectomy | ||
[2] | 69 years | Intrasplenic, (3.6×108 cells and 1.7×108 cells), encephalopathy grade 4 unchanged, died on day 2. |
Herpes II | ||
[6] | 29 years | Intraportal + intrasplenic (1×1010 cells), encephalopathy grade 4 unchanged, O2 ↓. Died after 18 hours. |
[4] | 37 years | Intrasplenic, (1.2×108 cells), NH3 ↓ and encephalopathy grade 4 improved. Died on day 5 from sepsis. |
HBV | ||
[6] | 65 years | Intraportal + intrasplenic, (3×1010 cells), encephalopathy grade 3 improved, NH3 ↓ & O2 ↓, multisystem organ failure on day 52. |
[2] | 28 years | Intrasplenic, (1.69×108 cells), NH3 ↓ and encephalopathy grade 4 improved, OLT day 3, full recovery. |
[2] | 43 years | Intraportally, (2.43×108 cells × 3), encephalopathy 4, OLT on day 1, full recovery. |
[5] | 40 years | Intraperitoneal, (6×107 cells/kg body weight), encephalopathy grade 4 unchanged. Died after 13 hours. |
HBV + cocaine | ||
[9] | 37 years | Intrasplenic, (8.8×108 cells), NH3 ↓ and encephalopathy grade 2 improved, full recovery with 7-year follow-up. |
HBV + lymphoma | ||
[3] | 54 years | Intraportal, (6.6×109 cells), NH3 ↓ and encephalopathy grade 2 improved, multisystem organ death day 7. |
HSV 1 | ||
[10] | 15 days | Alginate encapsulated hepatocytes (2×107/kg) were transplanted by intraperitoneal injection. INR was normalized by day 10. Patient survived without liver transplant. |
Adenovirus | ||
[10] | 17 months | Alginate encapsulated hepatocytes (2×107/kg) were transplanted by intraperitoneal injection. INR was normalized by day 6. Patient survived without liver transplant. |
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