Disorder | Aggregation response | Other features | |||
Primary ADP | Secondary ADP | Collagen | Ristocetin | ||
VWD | ++++ | ++++ | ++++ | Highly variable | Platelet morphology normal; VWD panel is usually abnormal |
Bernard-Soulier syndrome | ++++ | ++++ | ++++ | 0 | Giant platelets, thrombocytopenia; VWD panel is normal |
Glanzmann thrombasthenia | 0 | 0 | 0 | +++ | Normal platelet morphology |
Storage pool disease | ++++ | 0 to ++ | ++ | ++ | Platelet morphology normal (except in gray platelet subgroup); electron microscopy is abnormal |
Secretion defect | ++++ | 0 to ++ | ++ | ++ | Normal morphology by light and electron microscopy |
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