Adverse event | Evaluation | Management |
Dyspnea | PFTs Chest X-ray Chest CT scan CBC |
If imaging does not reveal ILD, provide supportive care and treat other factors contributing to dyspnea (eg, anemia) If imaging suggests interstitial lung disease, see below for management |
ILD in asymptomatic patients | PFTs Chest CT scan |
No specific therapy or drug interruption if PFTs are normal and radiographic changes are mild |
ILD in patients with mild symptoms | PFTs Chest CT scan |
May require temporary treatment interruption, depending on severity of PFT and CT abnormalities Will need ongoing monitoring of PFTs and chest CT |
ILD in patients with underlying lung disease or moderate symptoms/PFT/CT abnormalities | PFTs Chest CT scan Diagnostic testing for opportunistic infection |
May require temsirolimus discontinuation Will need frequent monitoring of PFTs and chest CT |
ILD in patients with severe or progressive symptoms/PFT abnormalities | PFTs Chest CT scan Diagnostic testing for opportunistic infection |
Discontinue temsirolimus Administer high dose glucocorticoids |
Do you want to add Medilib to your home screen?