Situation | Potential organisms encountered | Agent | Regimen: single oral dose 30 to 60 minutes before procedure |
Prevention of surgical site infection | |||
Surgery involving glabrous skin, nonoral |
| Cephalexin | 2 g |
OR | |||
Clindamycin | 600 mg | ||
OR | |||
Azithromycin or clarithromycin | 500 mg | ||
Surgery involving ear, groin, or lower extremities (below the knee) |
| Cephalexin | 2 g |
OR | |||
Trimethoprim-sulfamethoxazole | 160 mg trimethoprim/800 mg sulfamethoxazole | ||
OR | |||
Ciprofloxacin | 500 mg | ||
Any site, increased risk of MRSA infection | Clindamycin | 600 mg | |
OR | |||
Trimethoprim-sulfamethoxazole | 160 mg trimethoprim/800 mg sulfamethoxazole | ||
Prevention of infective endocarditis or hematogenous total joint infection in patients at high risk | |||
Surgery involving the oral mucosa |
| Amoxicillin | 2 g |
OR | |||
Cephalexin | 2 g | ||
OR | |||
Clindamycin | 600 mg | ||
OR | |||
Azithromycin or clarithromycin | 500 mg | ||
Surgery involving infected skin (eg, incision and drainage of skin abscess) |
| Cephalexin | 2 g |
OR | |||
Clindamycin | 600 mg | ||
OR | |||
Azithromycin or clarithromycin | 500 mg | ||
Any site, increased risk of MRSA infection | Clindamycin | 600 mg | |
OR | |||
Trimethoprim-sulfamethoxazole | 160 mg trimethoprim/800 mg sulfamethoxazole |
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