Subnormal response to metyrapone in hypopituitarism

Serum concentrations of 11-DOC after the administration of metyrapone (750 mg every four hours for six doses) in normal subjects and patients with hypopituitarism. The serum 11-DOC concentrations are much lower in the patients with hypopituitarism, due to the inability to substantially increase the secretion of ACTH. To convert serum 11-DOC values to nmol/L, multiply by 28.9.