Complications of iron overload | Expected treatment outcome |
None | Prevention of complications of iron overload; normal life expectancy |
Weakness, fatigue, lethargy | Improvement in majority of patients |
Elevated serum concentrations of hepatic enzymes | Resolution or marked improvement |
Hepatomegaly | Resolution often occurs |
Hepatic cirrhosis | No change |
Increased risk for primary liver cancer | No change* |
Right upper quadrant pain | Resolution or marked improvement¶ |
Arthropathy | Improvement in arthralgias sometimes occurs; change in joint deformity is rare; progression is sometimes seen |
Hypogonadotrophic hypogonadism | Resolution is rare |
Diabetes mellitus | Occasional improvement, often temporary |
Hypothyroidism, hypogonadism | Resolution is rare |
Cardiomyopathy | Resolution sometimes occurs |
Hyperpigmentation | Resolution usually occurs |
Hyperferritinemia | Resolution |
Excess absorption and storage of nonferrous metalsΔ | |
Infection with Vibrio vulnificus or other bacteria | Little or no change |
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