Cycle length: Weekly. | |||
Drug | Dose and route | Administration | Given on days |
Temsirolimus | 25 mg IV* | Dilute in 250 mL NS¶ and infuse via an infusion pump over 60 minutes for the first dose.Δ Subsequent doses may be given over 30 minutes if tolerated. | Once weekly |
Pretreatment considerations: | |||
Emesis risk |
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Prophylaxis for infusion reactions |
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Dose adjustment for baseline liver dysfunction |
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Monitoring parameters: | |||
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Suggested dose modifications for toxicity: | |||
Myelotoxicity |
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ANC: absolute neutrophil count; AST: aspartate aminotransferase; CBC: complete blood count; DEHP: di (2-ethylhexyl) phthalate; IV: intravenous; NS: normal saline; PVC: polyvinyl chloride; ULN: upper limit of normal.
* Total dose, not adjusted for weight or body surface area.
¶ Diluent solutions should not be modified without consulting a detailed reference due to potential incompatibility(ies).
Δ Administer through an inline 5-micron (or smaller), polyethersulfone filter. Do not use DEHP-containing (PVC) containers or administration sets.[2]Do you want to add Medilib to your home screen?