Component | (mcg/mL) | Function |
Classical pathway (CP) | ||
C1 | 50 | Binds immune complexes to trigger classical pathway |
C1q subcomponent | Binds Fc portion of IgG/IgM | |
C1r subcomponent | Protease: Cleaves C1s | |
C1s subcomponent | Protease: Cleaves C4 and C2 | |
C4 | 200 to 500 | Opsonin* (C4b), C4a¶ |
C2 | 20 | Protease: Cleaves C3 and C5 as part of the convertases |
Lectin pathway (LP) | ||
MBLΔ | 150 (wide range) | Binds sugars to trigger LP |
MASP-1 | 5 | Protease: Cleaves MASP-2 and C4 |
MASP-2 | 5 | Protease: Cleaves C4 and C2 |
Alternative pathway (AP) | ||
Factor D | 1 to 2 | Protease: Cleaves factor B to Ba and Bb |
Factor B | 150 to 250 | Protease: Cleaves C3 and C5 as part of the convertases |
Properdin | 25 | Stabilizes AP convertases |
Central protein | ||
C3 | 550 to 1200 | Opsonin* (C3b), C3a¶ |
Terminal pathway (TP) | ||
C5 | 70 | MAC component is C5b; C5a¶ (anaphylatoxin) is released |
C6 | 60 | MAC component |
C7 | 60 | MAC component |
C8 | 60 | MAC component (pore formation) |
C9 | 60 | MAC component (pore formation) |
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