Plasmapheresis | Intravenous immune globulin (IVIG) | |
Usual adult dose | 5 exchange treatments of 3 to 5 liters with 5% albumin over 7 to 14 days | 2 g/kg in evenly divided doses over 2 to 5 days Examples: 400 mg/kg daily for 5 days or 1 g/kg on 2 consecutive days*[1] |
Onset of effect | 1 to 7 days | 1 to 2 weeks |
Maximal effect | 1 to 3 weeks | 1 to 3 weeks |
Adverse effects | Line infection, hypotension, thromboembolism, bleeding, adverse reaction(s) to citrate anticoagulant added during procedure (hypocalcemia, metabolic alkalosis) | Rate-related reactions (common): headache, chills, flushing, low backache, nausea, tachycardia, dyspnea Delayed reactions (rare): thromboembolism, kidney failure, hematologic complications (hemolysis, neutropenia) Other (rare): transfusion-related acute lung injury (TRALI), transfusion-associated circulatory overload (TACO), hypersensitivity (eg, anaphylaxis) |
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