Version October 2024
| Medication | Low-dose | Medium-dose | High-dose |
| ICS-SABA combination | |||
| Budesonide-albuterol HFA (Brand name: Airsupra)* | |||
| NOTE: Not used for maintenance therapy. Acute symptom relief: Budesonide-albuterol (80 mcg/90 mcg) 2 inhalations as needed (usual maximum: 12 inhalations/day). | |||
| ICS-LABA combinations | |||
| Beclomethasone [beclometasone]-formoterol DPI or HFA (Not available in United States or Canada, but available elsewhere [sample brand names: Formodual, Fostair, Foster])¶Δ | |||
| 100 mcg/6 mcg | 1 inhalation twice daily | 2 inhalations twice daily | |
| 200 mcg/6 mcg | 2 inhalations twice daily | ||
| Budesonide-formoterol HFA (Brand names: Symbicort, Breyna)¶ | |||
| 80 mcg/4.5 mcg | 2 inhalations twice daily | ||
| 160 mcg/4.5 mcg | 2 inhalations twice daily | ||
| Fluticasone furoate-vilanterol DPI (Brand name: Breo Ellipta)Δ | |||
| NOTE: Inhaled fluticasone furoate has a greater anti-inflammatory potency per microgram than fluticasone propionate inhalers. Thus, fluticasone furoate is administered at a lower daily dose and used only once daily. | |||
| 50 mcg/25 mcg◊ | 1 inhalation once daily | ||
| 100 mcg/25 mcg | 1 inhalation once daily | ||
| 200 mcg/25 mcg | 1 inhalation once daily | ||
| Fluticasone propionate-formoterol MDI (Not available in United States or Canada, but available elsewhere [sample brand name: Flutiform]) | |||
| 50 mcg/5 mcg | 2 inhalations twice daily | ||
| 125 mcg/5 mcg | 2 inhalations twice daily | ||
| 250 mcg/10 mcg | 2 inhalations twice daily | ||
| Fluticasone propionate-salmeterol DPI (Brand names: Advair Diskus, Wixela Inhub)Δ | |||
| 100 mcg/50 mcg | 1 inhalation twice daily | ||
| 250 mcg/50 mcg | 1 inhalation twice daily | ||
| 500 mcg/50 mcg | 1 inhalation twice daily | ||
| Fluticasone propionate-salmeterol HFA (Brand name: Advair HFA) | |||
| 45 mcg/21 mcg | 2 inhalations twice daily | ||
| 115 mcg/21 mcg | 2 inhalations twice daily | ||
| 230 mcg/21 mcg | 2 inhalations twice daily | ||
| Fluticasone propionate-salmeterol DPI (Brand names: AirDuo RespiClick, AirDuo Digihaler)Δ§ | |||
| 55 mcg/14 mcg | 1 inhalation twice daily | ||
| 113 mcg/14 mcg | 1 inhalation twice daily | 1 inhalation twice daily | |
| 232 mcg/14 mcg | 1 inhalation twice daily | ||
| Mometasone-formoterol HFA (Brand name: Dulera) | |||
| 100 mcg/5 mcg | 1 inhalation twice daily | 2 inhalations twice daily | |
| 200 mcg/5 mcg | 2 inhalations twice daily | ||
| Mometasone-indacaterol DPI (Brand name: Atectura Breezhaler; available in Canada)Δ | |||
| 80 mcg/150 mcg | 1 inhalation (capsule) once daily | ||
| 160 mcg/150 mcg | 1 inhalation (capsule) once daily | ||
| 320 mcg/150 mcg | 1 inhalation (capsule) once daily | ||
| ICS-LAMA-LABA combinations¥ | |||
| Fluticasone furoate-umeclidinium-vilanterol DPI (Brand name: Trelegy Ellipta)Δ | |||
| 100 mcg/62.5 mcg/25 mcg | 1 inhalation once daily | ||
| 200 mcg/62.5 mcg/25 mcg | 1 inhalation once daily | ||
| Mometasone-glycopyrrolate (glycopyrronium)-indacaterol DPI (Brand name: Enerzair Breezhaler; available in Canada)*Δ | |||
| 160 mcg/50 mcg/150 mcg | 1 inhalation (capsule) once daily | ||
DPI: dry powder inhaler; HFA: metered-dose inhaler with hydrofluoroalkane propellant; ICS: inhaled glucocorticoid (inhaled corticosteroid); LABA: long-acting beta-agonist; LAMA: long-acting muscarinic antagonist; SABA: short-acting beta-agonist; SMI: soft mist inhaler.
* Not approved for use in patients <18 years old.
¶ When using ICS-formoterol as reliever, use one to two inhalations as needed. Maximum daily dose of maintenance and rescue is 12 inhalations.
Δ DPI contains lactose which may have small amounts of milk protein.
◊ Fluticasone furoate-vilanterol 50 mcg/25 mcg DPI is approved for use in patients 5 to 11 years old; use in adolescents and adults is off-label.
§ In AirDuo inhalers, the daily dose of salmeterol is approximately one-fourth of the dose in Advair, and the daily dose of fluticasone is approximately one-half that of the comparable low-, medium-, and high-dose strengths of Advair.
¥ Alternatively, tiotropium SMI (Brand name: Spiriva Respimat) can be used with an ICS or ICS-LABA inhaler. The dose in asthma is two inhalations (1.25 mcg/inhalation) once daily.Do you want to add Medilib to your home screen?
