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NK/T cell lymphoma prognostic index (NKPI) for extranodal NK/T cell lymphoma, nasal type

NK/T cell lymphoma prognostic index (NKPI) for extranodal NK/T cell lymphoma, nasal type
Presence of systemic B symptoms*
Ann Arbor stage III or IV disease
Elevated lactate dehydrogenase
Regional lymph node involvement
One point is given for each of the above characteristics present in the patient, for a total score ranging from zero to four. When applied to retrospective series of patients with extranodal NK/T cell lymphoma, five-year overall survival (OS) and rates of central nervous system (CNS) involvement without prophylaxis according to score were as follows:
Score OS, percent[1] CNS involvement, percent[2]
0 81 <2
1 64 <2
2 34 <2
3 or 4 7 10
* Systemic B symptoms are defined as temperature >38°C (>100.4°F), unexplained weight loss of >10 percent of body weight over the past six months, and/or the presence of drenching night sweats.
¶ Regional lymph node involvement was defined as the invasion of lymph nodes corresponding to N1, N2, or N3 of the primary lesion in the American Joint Committee on Cancer tumor (T), nodes (N), metastasis (M) staging system. An example of regional lymph node involvement is the involvement of cervical nodes for patients with NK/T cell lymphoma of the upper aerodigestive tract.
References:
  1. Lee J, Suh C, Park YH, et al. Extranodal natural killer T-cell lymphoma, nasal-type: a prognostic model from a retrospective multicenter study. J Clin Oncol 2006; 24:612.
  2. Kim SJ, Oh SY, Hong JY. When do we need central nervous system prophylaxis in patients with extranodal NK/T-cell lymphoma, nasal type? Ann Oncol 2010; 21:1058.
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