Estimate glomerular filtration rate to assess specific risk of hyperkalemia |
Discontinue nonsteroidal antiinflammatory drugs and other drugs that interfere with renal potassium excretion |
Inquire about use of herbal preparations |
Prescribe a low-potassium diet |
Inquire about use of potassium-containing salt substitutes |
Prescribe thiazide or loop diuretics to increase potassium excretion |
Prescribe sodium bicarbonate to correct metabolic acidosis if present |
When initiating ACE inhibitor, angiotensin receptor blocker, or mineralocorticoid receptor antagonist, use low doses |
Measure serum potassium concentration one week after initiating therapy or after increasing dose of these agents |
If hyperkalemia develops (refer to content on specific drugs for thresholds), reduce or discontinue the drug(s) causing hyperkalemia. |
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