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Factors associated with refractoriness to platelet transfusion

Factors associated with refractoriness to platelet transfusion
Non-immune
Fever, sepsis, or infection
Splenomegaly
DIC
Bleeding
Medications, especially amphotericin and heparin
Hematopoietic stem cell transplant
Alloimmune
Anti-HLA antibodies (typically anti-HLA-A and anti-HLA-B)
Anti-HPA antibodies
Refer to UpToDate for additional discussion of the mechanisms of platelet refractoriness and patient evaluation and management.
DIC: disseminated intravascular coagulation; HLA: human leukocyte antigen; HPA: human platelet antigen.
Graphic 67416 Version 4.0