Study | Cephalosporin reaction rate | Cephalosporins administered | Type of reaction (causative drug) | |
History of penicillin allergy (%) | No history of penicillin allergy (%) | |||
Dash (1975)[1] | 25 of 324 (7.7%) | 140 of 17,216 (0.8%) | Cephalexin and cephaloridine | No details given |
Petz (1978)[2] | 57 of 701 (8.1%) | 285 of 15,007 (1.9%) | Cephalexin, cephaloridine, cephalothin, cefazolin, and cefamandole | No details given |
Goodman (2001)[3] | 1 of 300 (0.3%) | 1 of 2431 (0.04%) | Cefazolin (in all but one patient) | Reaction was questionable |
Daulat (2004)[4] | 1 of 606 (0.17%) | 15 of 22,664 (0.07%) | First generation (42%) | Reaction was eczema (cefazolin) |
Second generation (21%) | ||||
Third/fourth generation (37%) | ||||
Fonacier (2005)[5] | 7 of 83 (8.4%) | Not applicable | First generation (59%) | Reactions were convincing: (Cephalexin-1) |
Second generation (8.4%) | (Cefaclor-2, cefuroxime-2) | |||
Third generation (25%) | (Cefixime-1, ceftriaxone-1) | |||
Fourth generation (7%) | ||||
MacPherson (2006)[6] | 0 of 84 (0) | Not applicable | Cefazolin, cefotetan, ceftriaxone | |
Crotty (2015)[7] | 7 of 186 (3.8%) | Not applicable | Cephalexin, cefoxitin, ceftriaxone, and cefepime | Six of seven reactions were due to cefepime; three of seven reactions were immediate |
Beltran (2015)[8] | 1 of 153 (0.7%) | Not applicable | Cefazolin (84%) Cefoxitin (17%) | Reaction was urticarial (cefazolin) |
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