Langerhans cell histiocytosis extensively involving lymph node in a patient with widespread disease and symptoms. The Langerhans cells have inconspicuous nucleoli, thin nuclear membranes, and prominent folding of their nuclear contours, imparting a "twisted towel" appearance.
(A) Low-power view showing subtotal replacement of lymph node.
(B) High-power magnification showing cytologic features of Langerhans cells and a mitotic figure. Hematoxylin-eosin stains.
Reproduced with permission from: Ioachim HL, Medeiros LJ. Dendritic cell neoplasms. In: Ioachim's Lymph Node Pathology, 4th ed, Lippincott Williams & Wilkins, Philadelphia 2009. Copyright © 2009 Lippincott Williams & Wilkins.
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